For Research Use Only — Not for Human or Veterinary Use
KLOW Refill 80mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the AbsoluteBioLab Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
KLOW Refill 80mg — Kisspeptin-10 GnRH Axis Neuroendocrine Research Compound Refill Cartridge for the AbsoluteBioLab Peptide Pen v3
The KLOW Refill 80mg is a pre-filled lyophilised refill cartridge containing research-grade KLOW, a proprietary neuroendocrine research compound for GnRH axis research. This refill format is designed for direct use with the AbsoluteBioLab Reusable Metal Peptide Pen v3, providing a convenient and reproducible format for pre-clinical neuroendocrine research programmes requiring repeated administration.
Each refill cartridge contains 80mg of lyophilised KLOW, verified by RP-HPLC to a minimum purity of ≥99.0%, with molecular identity confirmed by ESI-MS. Endotoxin content is certified at <1.0 EU/mg by kinetic turbidimetric LAL assay. A batch-specific Certificate of Analysis is included with every order.
The 80mg refill format provides a substantial quantity for research programmes with ongoing KLOW requirements, offering a cost-effective and convenient alternative to repeated small-volume purchases. The refill cartridge is compatible with the AbsoluteBioLab Reusable Metal Peptide Pen v3, providing a consistent delivery format for pre-clinical in vivo research programmes investigating the GnRH axis and neuroendocrine regulation of reproductive function.
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | KLOW (proprietary neuroendocrine research compound) |
| Quantity per Cartridge | 80 mg |
| Salt Form | Acetate salt (lyophilised) |
| Primary Research Area | GnRH axis; neuroendocrine regulation; reproductive research |
| Research Classification | Neuroendocrine research compound; GnRH axis modulator |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | AbsoluteBioLab Peptide Pen v3 | Use with 4mm 31G pen needles |
Mechanism of Action
KLOW acts within the GnRH (gonadotropin-releasing hormone) axis, the central neuroendocrine pathway that regulates reproductive function through the hypothalamic-pituitary-gonadal (HPG) axis. The GnRH axis integrates metabolic, environmental, and circadian signals to regulate the pulsatile release of GnRH from hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurons, which in turn drives pulsatile LH and FSH secretion from the anterior pituitary and downstream gonadal steroidogenesis.
Research into GnRH axis regulation has identified multiple neuroendocrine peptides and signalling molecules that modulate GnRH pulse frequency and amplitude, including kisspeptin (acting through KISS1R/GPR54), neurokinin B (acting through NK3R), and dynorphin (acting through KOR). These KNDy neuron-derived peptides form an autocrine/paracrine regulatory circuit that generates the GnRH pulse generator activity, and their modulation by metabolic signals (leptin, insulin, ghrelin) and gonadal steroids (oestradiol, testosterone) provides the mechanistic basis for the integration of metabolic status and reproductive function.
Pre-clinical research into GnRH axis modulators uses a range of in vitro and in vivo models including hypothalamic explant preparations (for GnRH pulse measurement), pituitary cell cultures (for LH/FSH secretion assays), and intact rodent models (for LH pulse analysis by frequent blood sampling). The refill cartridge format is particularly suited to research programmes requiring repeated subcutaneous administration in pre-clinical GnRH axis studies, providing consistent, pre-measured doses with minimal handling variability.
Research Applications & Reconstitution
KLOW Refill 80mg is used in pre-clinical neuroendocrine and reproductive research. Key applications include studies of GnRH axis regulation and the role of neuroendocrine peptides in modulating GnRH pulse frequency and amplitude; investigations of the HPG axis in rodent models of reproductive dysfunction, hypogonadism, and metabolic-reproductive interactions; studies of the effects of GnRH axis modulators on LH and FSH secretion, gonadal steroidogenesis, and reproductive behaviour; and investigations of the neuroendocrine mechanisms underlying the metabolic regulation of reproductive function. The 80mg refill format provides a substantial quantity for ongoing research programmes.
This refill cartridge is supplied in lyophilised form and must be reconstituted before use. For use with the AbsoluteBioLab Peptide Pen v3, reconstitute with bacteriostatic water to the desired concentration. A typical reconstitution is 2ml bacteriostatic water per 10mg cartridge to yield a 5mg/ml solution. Allow the lyophilised cake to dissolve completely by gentle swirling — do not vortex. The reconstituted solution should be clear and colourless; discard if particulate matter or discolouration is observed. For in vitro applications, reconstitute in sterile PBS (pH 7.4) or cell culture-grade water.
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
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